![]() However, now it smells like fraud to continue selling this software that does not even run on fully patched operating systems. GCK has not received any feature updates for perhaps 10 years. I was not very surprised to realize that GCK is now almost abandonware. ![]() I needed Google to help me find this blog post from the GCK developers. I went to the GCK homepage but could not find anything in the FAQ section. Unlike Windows, which goes a long way to maintain backward compatibility, macOS seems constantly to make changes that break older software. GCK 4.5 does not run under macOS 10.15 Catalina and never will After downloading and installing GCK (which had been meanwhile updated to version 4.5), the app icon appeared greyed out and crossed out: This app is too old to run on macOS 10.15 (which is also already 2.5 years old). But of course, at the moment our IT is again hopelessly behind as everybody else is moving to WireGuard, which is conceptually easier and better performing. Hopefully, IT has learned the lesson that you cannot buy security with money. Then it appeared that Pulse Secure was just pretending to be secure. IT soon realized that the license fees would be too expensive to allow everybody to use a VPN and therefore our university was running two parallel VPN solutions: Pulse Secure and OpenVPN (the latter being free). After about 2 hours, I had downloaded and installed all updates and was even able to manually delete "Pulse Secure" ( Pulse Secure was the horrendously insecure "secure communication" tool that the university IT wanted the whole university to use a few years back. ![]() After booting, I first needed to install an onslaught of updates, without which I was permanently bombarded with pop-ups that asked me to bin "Pulse Secure" and "navlibx". The 2013 Macbook had been upgraded to run macOS 10.15 (Catalina) perhaps a year ago when I last time used it. I needed to use my old 2013 Macbook because GCK runs only on Mac and Windows, and all my PCs are running Linux. Updating macOS and getting rid of constantly nagging pop-ups To open this file I needed to install GCK on one of my computers. gci (Illustration) files cannot be opened by SnapGene. We had used GCK until 2013 when we replaced it with the much better designed and more capable SnapGene. But how to open it? The actual GCK sequence files can be opened by the contemporary DNA construct mapping and cloning software SnapGene. And since I never delete anything, the file was still in my "Documents/Sequences/GCK/pSecTag/pSecTagI" folder. gci file for the construction of pSecTagI, which does contain a detailed description of the cloning. However, it was possible to manually create so-called Illustration files (.gci file extension), which could be used to manually document complex cloning projects and to create figures for manuscripts or presentations. Gene Construct Kit GCK has had the peculiarity that it did not store the history of the construction. Last Wednesday, I spent 4 hours of my working time opening one file created with GCK version 2.5 in 1999. We were at the "cutting edge" of technology because we used a software program called Gene Construction Kit (GCK) to keep track of our clonings. I was working in Kari Alitalo's laboratory as a Ph.D.
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